Late‐onset Hypogonadism: Bone health

Male Hypogonadism and Osteoporosis: The Effects, Clinical Consequences, and Treatment of Testosterone Deficiency in Bone Health

It is well recognized that bone loss accelerates in hypogonadal states, with female menopause being the classic example of sex hormones affecting the regulation of bone metabolism. Underrepresented is our knowledge of the clinical and metabolic consequences of overt male hypogonadism, as well as the more subtle age-related decline in testosterone on bone quality. While menopause and estrogen de...

Immobilization hypercalcaemia with severe bone mineral loss and hypogonadism.

Moderate hypercalcaemia occurred in a 17-year-old male who was immobilized with abdominal and right hip sepsis for 9 months after a motor vehicle accident. The hypercalcaemia was due to bone resorption, with a urine hydroxyproline:creatinine ratio of 0.203 (normal less than 0.017) and a urine calcium loss of 22.9 mmol/24 hr, associated with impaired renal function. There was radiological eviden...

I-3: Hypogonadotropic Hypogonadism

Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility and a congenital or secondary disorder characterized by delayed or absent sexual maturation. Congenital abnormalities leading to HH are usually the consequence of deficient GnRH secretion occurring either in isolation (idiopathic hypogonadotropic hypogonadism (IHH)), or in association with anosmia (Kallmann syndrome; KS...

Bone Up on Bone Health

Bone disease has reached near-epidemic proportions in America. Millions of people are suffering the often-crippling and devastating effects of diseases such as osteoporosis, a condition that results in a "demineralization" of the bone matrix, causing bones to become less dense over time and increasing the risk of fractures, especially of the spine, wrist and hip; and osteopenia (softening of th...

Bone deficit and bone health.